Polymer 2.x/3.x brought the standards-compliant ES6 class-based syntax for defining Web Components. This works well for most modern browsers and ES6 has a lot of other nice features (like arrow functions) to make your JS code cleaner and more fun to write.
But if you need to support older browsers like IE 11 you will have to compile your code to ES5 which comes with performance drawbacks for modern browsers compared to running ES6 on them directly.
The ideal approach is to use differential serving to serve the ES6 version to modern browsers and a fallback ES5 version to older browser. prpl-server-node is a sample implementation of a Node server that uses this pattern. I took the ideas from this implementation and created a sample based on the polymer-starter-kit on how you can use differential serving on Firebase Hosting using Cloud Functions for Firebase for dynamically sending the right version to the user.
Since blogger has started to look quite old I'm currently testing Medium, so you will find the rest of this article there: https://medium.com/@scarygami/differential-serving-on-firebase-hosting-f83c33b83a8e